神经损伤与功能重建Issue(3)：208-211,4.DOI:10.3870/sjsscj.2013.03.014
精神分裂症患者伦敦塔任务下执行功能的比较研究
Comparative Study of Executive Function of Schizophrenia Patients in Tower of London
吴士豪 1陈诚 1邹寄林 1黄欢 1王熇生 1舒畅 1王惠玲1
作者信息
- 1. 武汉大学人民医院精神卫生中心武汉 430060
- 折叠
摘要
Abstract
Objective:To study the executive function of schizophrenia patients in completing different diffi-culty level of Tower of London (TOL), and to confirm the suitability of TOL as a cognitive assessment tool for schizophrenia patients. Methods:Twenty-seven schizophrenia patients (patients group) and 28 healthy volun-teer (control group) were given computerized TOL assessment. The response time and correct rate would be collected and analyzed. Results:On medium difficulty questions, patients and control groups didn’t have a dif-ference in time required for solving TOL items. However, time required on solving problems were significantly higher in easy and difficult questions (P<0.05), and the accuracy was significantly lower than the control group in all difficulties (P<0.01). In addition, a within group comparison showed significant lengthening of time and lowering of accuracy when comparing between easy and difficult levels (P<0.001). Moreover, the problem solving time of TOL was positively correlated to cognitive symptoms in easy level (r=0.499, P<0.05), while in higher difficulties, problem solving time was negatively correlated to excitability-Hostility symptoms (r=-0.452, P<0.05;r=-0.553, P<0.05);also, the correct response rate is negatively correlated to cognitive symp-toms in higher difficulties (r=-0.438, P<0.01;r=-0.672, P<0.01). Conclusion:TOL may be a suitable tool for cognitive ability assessment, while the cognitive function may be affected by impulse and cognitive related symptoms.关键词
精神分裂症/伦敦塔测验/认知功能Key words
schizophrenia/Tower of London/cognitive function引用本文复制引用
吴士豪,陈诚,邹寄林,黄欢,王熇生,舒畅,王惠玲..精神分裂症患者伦敦塔任务下执行功能的比较研究[J].神经损伤与功能重建,2013,(3):208-211,4.
