神经损伤与功能重建Issue(4)：266-269,303,5.DOI:10.3870/sjsscj.2013.04.010
幽门螺杆菌感染与缺血性卒中及其亚型关系的Meta分析
Meta-analysis of a Relationship between Helicobacter Pyloric Infection and Ischemic Stroke
于晓东 1王淑杰 2陈忠云 3李珊珊 3李婧 3徐志伟 3邢岩4
作者信息
- 1. 沈阳二0一医院院部沈阳110043
- 2. 廊坊职业技术学院校医院河北廊坊065000
- 3. 航天中心医院 北京大学航天临床医学院神经内科北京100049
- 4. 航空总医院神经内科北京100012
- 折叠
摘要
Abstract
Objective:To systematically review the relationship between helicobacter pyloric (Hp) infec-tion and ischemic stroke (IS) and its subtypes. Methods:We have collected Case-control studies concern-ing the relationship between HP infection and IS and its subtypes, by searching the electronic bibliograph-ic databases. Meta-analysis was conducted based on the methods recommended by the Cochrane Collabo-ration. Heterogeneity test, sensitivity analysis and publication bias assessment were also performed. Re-sults:Fifteen case-control studies, 2122 cases with IS and 2398 controls, were included. The difference in infection ratio of HP between the patients with IS and the controls was significant ( =1.61, 95%: 1.28~2.0). These differences were only found in the large-artery atherosclerosis (LAA) subgroup ( =1.83, 95% :1.49~2.25) and the small-artery atherosclerosis (SAA) subgroup ( =2.50, 95%:1.42~4.39), nor in the cardiogenic cerebral embolism (CE) subgroup ( =0.96, 95% :0.73~1.25). Sensitivity analysis suggested that the results of meta-analysis were reliable. The funnel plot suggested the presence of publication bias. Conclusion:HP infection is a risk factor fof IS. HP infection is more likely to occur in patient with LAA and SAA subtypes of strokes.关键词
幽门螺杆菌/缺血性脑卒中/Meta分析Key words
Helicobacter pyloric/ischemic stroke/Meta-analysis分类
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于晓东,王淑杰,陈忠云,李珊珊,李婧,徐志伟,邢岩..幽门螺杆菌感染与缺血性卒中及其亚型关系的Meta分析[J].神经损伤与功能重建,2013,(4):266-269,303,5.
