神经损伤与功能重建Issue(6)：494-496,3.DOI:10.3870/sjsscj.2015.06.008
重组组织型纤溶酶原激活物静脉溶栓治疗急性轻型脑梗死的疗效观察
Efficacy of Intravenous Thrombolysis with Recombinant Tissue-type Plasminogen Activator for Patients with Acute Mild Ischemic Stroke
解燕春 1曾艳平 1张少峰 1关景霞 1卢祖能1
作者信息
- 1. 武汉大学人民医院神经内科武汉 430060
- 折叠
摘要
Abstract
Objective: To investigate the safety and efficacy of intravenous thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) for acute mild ischemic stroke. Methods: Fifty-three acute mild ischemic stroke patients who presented symptoms within 4.5 h after onset were divided into rt-PA group (n=24) and control group (n=29). The patients in the both groups were given normal therapy, and the rt-PA group was given additional intravenous thrombolysis with rt-PA. The incidence of symptomatic intracranial haemorrhage (sICH) and mortali-ty at 90 d were used to assess the safety. Functional outcomes were assessed with NIHSS score before treatment and 2 h, 24 h, 7 d after treatment, the efficacy at 7 d and modified Rankin score (mRS) at 90 d. Results:No sICH and death occurred in the both groups. The NIHSS scores of rt-PA group at 2 h, 24 h after treatment were significantly lower than those of the control group (P<0.05). No significant difference was found in the NIHSS score at 7 d, the efficacy at 7 d, and the mRS at 90 d between the 2 groups (P>0.05). Conclusion: The safety and efficacy of mild ischemic stroke patients treated with rt-PA are similar to those in the patients with traditional treatment.关键词
重组组织型纤溶酶原激活剂/急性轻型脑梗死/静脉溶栓Key words
recombinant tissue-type plasminogen activator/acute mild cerebral ischemia/intravenous thromboly-sis分类
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解燕春,曾艳平,张少峰,关景霞,卢祖能..重组组织型纤溶酶原激活物静脉溶栓治疗急性轻型脑梗死的疗效观察[J].神经损伤与功能重建,2015,(6):494-496,3.
