神经损伤与功能重建Issue(6)：512-513,2.DOI:10.3870/sjsscj.2015.06.014
437例癫痫患儿血丙戊酸浓度监测分析
Analysis of Serum Concentrations of Valproic Acid in 437 Patients with Pediatric Epilepsy
摘要
Abstract
Objective:To provide references for clinical drug administration by analyzing the serum concentrations of valproic acid (VPA) in pediatric epilepsy. Methods: Enyme-mutiplied immunoassay technique (EMIT) was used to detect the serum concentrations of VPA in 437 pediatric epilepsy patients. The impact of age and sex on the serum concentrations of VPA and the relation between the serum concentrations of VPA and therapeutic effect were analyzed. Results: Among the serum concentrations of VPA in 437 cases, 51 cases(11.7%) were lower than 50μg/mL; 359 cases(82.2%) between 50 and 100 μg/mL; 27 cases( 6.2%) higher than 100 μg/mL. The impact of age and sex on the serum concentrations of VPA had no statistical difference (P>0.05), while the therapeutic effect be-tween 50~100 μg/mL group and <50 μg/mL group had statistical difference (χ2=55.10, P<0.05). Conclusion: The monitoring of VPA will be great important reference to drug administration for pediatric epilepsy patients.关键词
儿童癫痫/血药浓度监测/丙戊酸/个体化用药Key words
pediatric epilepsy/serum concentration monitor/valproic acid/individualized drug administration分类
医药卫生引用本文复制引用
韩瑞玲,邓巍,李艳,吴薇..437例癫痫患儿血丙戊酸浓度监测分析[J].神经损伤与功能重建,2015,(6):512-513,2.基金项目
国家自然科学基金 （）
