广西医学Issue(4)：414-417,4.DOI:10.11675/j.issn.0253-4304.2013.04.09
蛋白酪氨酸激酶抑制剂对肿瘤患者肝毒性作用的 Meta分析▲
Risk of Hepatotoxicity Induced by Protein Tyrosine Kinase Inhibitor in Cancer Patients:A Meta-Analysis
摘要
Abstract
Objective To investigate the risk of hepatotoxicity induced by protein tyrosine kinase inhibitor (TKI) in cancer patients.Methods A search for the related case-control studies on TKI for the treatment of cancer patients was conducted in databases including PubMed ,CNKI,CBM,Wangfang,and search engines such as Google , Baidu.The risk of hepatotoxicity induced by TKI was evaluated .Results A total of 6 case-control studies were included.A Meta-analysis showed that the risk of hepatotoxicity in the TKI group increased significantly compared with placebo group (pooled odds ratio(OR)=6.07,95%confidence interval(CI)=3.06-12.05);Taking AST elevation as an observation index,the pooled analysis suggested that the risk of hepatotoxicity increased significantly in the patients treated with TKI(OR=6.84,95%CI=2.87-16.28).Conclusion The risk of hepatotoxicity increases significantly in cancer patients treated with TKI,which suggests that the real-time detection and observation on the patients′liver function should be performed during the treatment .关键词
酪氨酸激酶抑制/病例对照/肿瘤/肝毒性/Meta分析Key words
Tyrosine kinase inhibitor/Case-control study/Cancer/Hepatotoxicity,Meta-analysis分类
医药卫生引用本文复制引用
刘锦新,陈奕芝,龙玲,吴狄..蛋白酪氨酸激酶抑制剂对肿瘤患者肝毒性作用的 Meta分析▲[J].广西医学,2013,(4):414-417,4.基金项目
广东省深圳市留深博士后科研资助项目（2013年）；广东省深圳市龙岗区医疗卫生科技计划项目 （）
