广西医学Issue(5)：548-550,3.DOI:10.11675/j.issn.0253-4304.2013.05.09
黄芪注射液对阿霉素中毒性小鼠心肌细胞凋亡及细胞线粒体膜电位的影响▲
Effect of Huangqi Injection on Mitochondrial Membrane Potential and Apoptosis in Mice with Adriamycin-Induced Cardiotoxicity
摘要
Abstract
Objective To observe the effect of Huangqi injection on mitochondrial membrane potential (MMP) and apoptosis in adriamycin-induced cardiotoxicity mice.Methods Sixty Kunming mice were randomly divided into five groups:Huangqi injection(large-dose,middle-dose,small-dose) group,adriamycin model group,and normal control group.A myocardial injury model of adriamycin-induced cardiotoxicity was established.The mice were killed 24 hours after experiment,and their hearts were taken out.Flow Cytometry was used to analyze MMP and apoptosis of myocardial cells . Results ①MMP of adriamycin model group was smaller than those of other groups (P<0.05);Huangqi injection groups showed higher MMP compared with normal control group (P<0.05).② The myocardial apoptosis rate in the adriamycin model group was higher than those in the normal control group ,Huangqi injection(middle-dose,small-dose) group(P<0.01),which showed no significant difference between adriamycin model group and large-dose Huangqi injection group(P>0.05).Conclusion Huangqi injection can keep MMP stable to inhibit the abnormal myocardial apoptosis and protect myocardial cells.关键词
黄芪注射液/阿霉素/细胞线粒体膜电位/心肌细胞凋亡/小鼠Key words
Huangqi injection/Adriamycin/Mitochondrial membrane potential/Myocardial apoptosis/Mouse分类
医药卫生引用本文复制引用
李海英,梁丽英,陶文..黄芪注射液对阿霉素中毒性小鼠心肌细胞凋亡及细胞线粒体膜电位的影响▲[J].广西医学,2013,(5):548-550,3.基金项目
广西中医学院科研课题（P2007032）；广西中医学院第一附属医院青年科研基金 （）
