广西医学Issue(6)：675-677,3.DOI:10.11675/j.issn.0253-4304.2013.06.04
IL-18基因启动子区-137G／C多态性与急性脑梗死关系的研究
Correlation between Polymorphism of Promoter Region of Interleukin-18 Gene at Position-137 G/C and Acute Cerebral Infarction
摘要
Abstract
Objective To investigate the correlation between polymorphism of promoter region of interleulin -18 (IL-18) gene at position -137G/C and serum IL-18 level with acute cerebral infarction .Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphism of promoter region of IL-18 gene at position -137G/C in 153 cases of acute cerebral infarction and 114 normal controls,and enzyme-linked immunosorbent assay (ELISA) was used to test serum IL-18 level in the two groups.Results There was significant difference in the genotype distribution and allele frequency of polymorphism of promoter region of IL -18 gene at position-137G/C between acute cerebral infarction group and normal controls (P<0.05).The risk of acute cerebral infarction to the carriers with C allele genetype increased to 1.672 times as compared with the cases without C allele genotype .The serum IL-18 level in the acute cerebral infarction group was significantly higher than the controls (P<0.05),and the carriers with C allele genotype showed significantly higher serum IL -18 levels compared with the cases without C allele genotype in acute cerebral infarction group (P<0.05).Conclusion The polymorphism of promoter region of IL-18 gene at position -137G/C is associated with the onset of acute cerebral infarction .The C allele genotype may lead to a high expression of IL-18,which plays a role on the occurrence and development of acute cerebral infarction by affecting serum IL-18 level,and may increase the risk of acute cerebral infarction .关键词
急性脑梗死/白介素-18/基因Key words
Acute cerebral infarction/Interleukin-18/Genotype分类
医药卫生引用本文复制引用
韦广粤,陈军宁,富学林,李作兴,蒋萍萍..IL-18基因启动子区-137G／C多态性与急性脑梗死关系的研究[J].广西医学,2013,(6):675-677,3.基金项目
广西卫生厅科研立项课题 （）
