广西医学Issue(6)：692-695,698,5.DOI:10.11675/j.issn.0253-4304.2013.06.09
2型糖尿病合并高同型半胱氨酸血症与缺血性血管疾病关系的研究
Relationship between Type 2 Diabetes Mellitus Combined with Hyperhomocysteinemia and Ischemic Cerebrovascular Disease
摘要
Abstract
Objective To investigate the relationship between type 2 diabetes mellitus (T2DM) combined with hyperhomocysteinemia(HHCY) and ischemic cerebrovascular disease ,and observe the effect of folic acid tablet and vitamin B6 table on HHCY.Methods Two hundred and seven T2DM patients complicated with HHCY were randomly divided into two groups,102 cases were treated with folic acid tablet and vitamin B 6 tablet(treatment group) and 105 cases were not treated with folic acid tablet and vitamin B 6 tablet(control group).Serum fasting blood-glucose (FBG),2-hour postprandial blood glucose(PBG) and homocysteine(HCY) levels were detected at regular intervals ,and the 5-year incidence of ischemic cerebrovascular disease was caculated.Results The patients in the two group were followed up for 5 years,and their blood glucose was controlled in the normal range .HCY level in the treatment group decreased to a normal range,which was significantly different from that before treatment and the controls (P<0.01).The incidence of ischemic cerebrovascular disease such as transient ischemic attack (TIA),cerebral infarction,lower limb vascular embolization,myocardial infarction and angina pectoris in the treatment group was significantly lower than that in the control group ( P <0.05).Conclusion HHCY is one of the important risk factors for the occurrence of ischemic cerebrovascular disease among T2DM patients;Folic acid and vitamin B 6 used in the early treatment of T2DM combined with HHCY can prevent and control ischemic cerebrovascular disease ;Determination of serum HCY level in T2DM patients may contribute to early prevention of ischemic cerebrovascular disease .关键词
2型糖尿病/高同型半胱氨酸血症/缺血性血管疾病Key words
Type 2 diabetes mellitus/Hyperhomocysteinemia/Ischemic cerebrovascular disease分类
医药卫生引用本文复制引用
洪雁,吴原..2型糖尿病合并高同型半胱氨酸血症与缺血性血管疾病关系的研究[J].广西医学,2013,(6):692-695,698,5.基金项目
广西南宁市科学研究与技术开发计划项目 （）
