广西医学2015，Vol.37Issue(8)：1106-1109,4.DOI:10.11675/j.issn.0253-4304.2015.08.17
超声背向散射积分技术在糖尿病肾病临床分期评估中的应用价值
value of ultrasonic integrated backscatter technology applied to clinical staging assessment of diabetic nephropathy
摘要
Abstract
Objective To investigate the value of ultrasonic integrated backscatter(IBS) technology applied to quantitative assessment of diabetic nephropathy of different clinical stages.Methods One hundred and eight patients with diabetic nephropathy were divided into GroupⅠ(stageⅠ,n=24),GroupⅡ(stageⅡ,n=20),GroupⅢ(stageⅢ,n=22),GroupⅣ(stageⅣ,n=22),GroupⅤ(stageⅤ,n=20),and 26 healthy volunteers during the same period were enrolled in normal control group.Three ultrasonic parameters of IBS were measured in renal cortex,renal medulla and renal sinus,including peak-peak intensity(PPI),average image intensity(AII) and standard deviation of image intensity(SDI),and the AII of renal cortex and medulla was standardized(AII%).The ultrasonic parameters with statistical difference were analyzed by ROC curve, and the diagnostic thresholds for diabetic nephropathy and its different stages were obtained.Results The comparison of the AII% of renal cortex and renal medulla among all groups showed that the AII%was in a sequence of control group<GroupⅠ,GroupⅡ<GroupⅢ<Group Ⅳ<GroupⅤ(P<0 05),but no significant differences between GroupⅠand Group Ⅱ(P>0.05) were observed.ROC curve analysis revealed that area under the curves of renal cortex AII%and renal medulia AII%for diabetic nephropathy and its different stages were both more than 0.7(P<0.05).The diagnostic thresholds of renal cortex AII% for diabetic nephropathy,stageⅠand Ⅱ,stage Ⅲ, stageⅣand stageⅤwere 0.732,0.725,0.744,0.789 and 0.815,respectively.While the diagnostic thresholds of renal medulla AII%for diabetic nephropathy,stageⅠandⅡ,stageⅢ,stageⅣand stageⅤwere 0.625,0.619,0.666,0.706 and 0.740,respectively.Conclusion The technology of IBS can discover diabetic nephropathy in early stage and monitor the progress of renal damage,and it may become an important approach to clinical staging assessment of diabetic nephropathy.关键词
糖尿病肾病/超声背向散射积分/临床分期/平均强度标准化值/诊断界限值Key words
Diabetic nephropathy/Ultrasonic integrated backscatter/Clinical staging/Standardized average image intensity/Diagnostic threshold分类
医药卫生引用本文复制引用
石超会,张树华,阚艳敏,马琳..超声背向散射积分技术在糖尿病肾病临床分期评估中的应用价值[J].广西医学,2015,37(8):1106-1109,4.基金项目
河北省科学技术研究与发展计划(10276105D-48) （10276105D-48）
