解放军医药杂志2015，Vol.27Issue(9)：39-46,8.DOI:10.3969/j.issn.2095-140X.2015.08.009
微生态制剂治疗2型糖尿病临床随机对照研究的meta分析及系统评价
A Meta-analysis and System Assessment of Micro-ecologic Agents in Treatment of Type 2 Diabetes Mellitus Pa-tients by Randomised Control Trial
摘要
Abstract
Objective To evaluate the effects of micro-ecologic agents on levels of glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and fasting serum insulin, and oxidative stress and inflammatory indexes in pa-tients with type 2 diabetes mellitus ( DM ) using meta-analysis. Methods The papers of randomized controlled trials ( RCT) were searched from Cochrane Library, PubMed, EMbase, Wiley, SCI, CNKI, VIP and CBM databases. The da-ta extraction and quality evaluation were performed for the selected papers, and then meta-analysis was performed using Rev-Man 5. 0 software. Results A total of 7 RCTs were included in this study with good study quality and little misregis-tration risk. The results of meta-analyses,showed that the HbA1c levels of patients with type 2 DM significantly decreased when the therapeutic time was equal or more than 8 weeks [SMD= -0. 60, 95% CI ( -1. 05 to -0. 15)], and levels of FPG [SMD= -0. 46, 95% CI ( -0. 86 to -0. 05)] and fasting serum insulin [SMD= -1. 01, 95% CI ( -2. 00 to -0. 02)] could be also effectively decreased after treatment of micro-ecologic agents. The levels of glutathion peroxi-dase [SMD=2. 77,95% CI (0. 05 to 5. 48)] of patients with type 2 DM effectively increased, and hs-CRP levels [SMD= -2. 89, 95% CI ( -5. 04 to -0. 74)] were effectively decreased after treatment of micro-ecologic agents. There was no adverse events in 6 RCTs during the treatment, and there was no report about adverse events in 1 RCT. Conclusion The adjunctive therapy with micro-ecologic agents may effectively control blood glucose, improve the oxida-tive stress state and decrease the systemic low-grade inflammatory reaction in a certain extent with good safety for patients with type 2 DM, but long-term efficacy and safety need to be verified by more RCTs with better quality, larger samples and long-term follow-up.关键词
微生态制剂/糖尿病,2型/Meta分析/系统评价/随机对照试验Key words
Micro-ecologic agents/Diabetes mellitus/type 2/Meta-analysis/System assessment/Randomized controlled trial分类
医药卫生引用本文复制引用
陈硕,马建伟,徐丽梅,孟庆扬,韩琦..微生态制剂治疗2型糖尿病临床随机对照研究的meta分析及系统评价[J].解放军医药杂志,2015,27(9):39-46,8.基金项目
首都医学发展基金(SF-2009-I-13) （SF-2009-I-13）
首都临床特色应用研究课题(Z121107001012011) （Z121107001012011）
