摘要
Abstract
Objective To investigate the effect of stress hyperglycemia ( SHG) on cardiac function and effective-ness of insulin intensive therapy for critical patients in ICU. Methods A total of 80 critical non-diabetic patients admit-ted to ICU were recruited in this study, and blood sugar levels were detected immediately after admission. The patients were divided into SHG patients (n=56) and the euglycemia group (n=24) according to detection results, and the SHG patients were randomly divided into the routine treatment subgroup (n=28) and the intensive treatment subgroup (n=28). Cardiac function, hospitalization condition and prognosis in the two groups were compared upon admission, and the improvement of cardiac function between and after the routine and the intensive treatments was observed. Results In SHG group, the levels of right atrial pressure ( RAP) , pulmonary arterial pressure ( PAP) , pulmonary arterial wedge pressure (PAWP) and brain natriuretic peptide ( BNP) were significantly higher, while the levels of cardiac output ( CO) , cardiac index ( CI) , partial pressure of oxygen ( PaO2 ) and partial pressure of carbondioxide ( PaCO2 ) were sig-nificantly lower than those in the euglycemia group. In the intensive treatment subgroup, the levels of RAP, PAP, PAWP and BNP were significantly lower, while the levels of CO, CI, PaO2 and PaCO2 were significantly higher than those before the treatment and in the routine treatment subgroup (P<0. 05). In the SHG group, the hospital days, total number of patients using mechanical ventilation, the time of mechanical ventilation and mortality rate were increased, compared with those in the euglycemia group, while the indexes in the intensive treatment subgroup were significantly decreased, com-pared with those in the routine treatment subgroup (P<0. 05). Conclusion The SHG can obviously affect the cardiac function of patients in ICU, and insulin intensive therapy can markedly improve the cardiac function.关键词
应激性高血糖/危重病/心功能/胰岛素Key words
Stress hyperglycemia/Critical illness/Cardiac function/Insulin分类
医药卫生
