解放军医药杂志2015，Vol.27Issue(10)：69-71,75,4.DOI:10.3969/j.issn.2095-140X.2015.10.018
基于耐药基因OPRD2探讨铜绿假单胞菌的临床感染特性
A Study on Clinical Infection Characteristics of P. Aeruginosa Based on the Drug Resistance Gene OPRD2
摘要
Abstract
Objective To investigate the clinical infection distribution of Pseudomonas Aeruginosa ( P. Aerugi-nosa) in Beijing Hospital of TCM in 2014, and to analyze the characteristics of its drug resistance. Methods A total of 15 620 samples of infection cases in 2014 were isolated, and the P. Aeruginosa was reserved. The drug sensitivities a-gainst 20 antibiotics were detected using minimal inhibitory concentration ( MIC) method, and the detection for drug re-sistance gene outer membrane protein D2 (OPRD2) was performed in whole drug resistant P. Aeruginosa strains. Results A total of 5075 pathogens were isolated in this study, including the 332 P. Aeruginosa strains (6. 54%). The samples mostly came from phlegm, and the infection mostly occurred in the sores ulceration, respiratory diseases and ICU depart-ments. The isolated P. Aeruginosa had the most sensitivity against Amikacin, and the highest drug resistance rate against Cephazolin. The 9 P. Aeruginosa strains were total drug resistant against 20 antibiotics, and their OPRD2 drug resistance genes were not all lost. Conclusion The rate of P. Aeruginosa infection is high with wide range in clinical practice. To strengthen the monitoring of the P. Aeruginosa infection and drug resistance, especially to strengthen the surveillance of related genes of drug resistance may provide the basis for the reasonable treatment.关键词
耐药基因/临床感染/铜绿假单胞菌/细菌外膜蛋白Key words
Drug resistance gene/Clinical infection/Pseudomonas aeruginosa/Bacterial outer membrane pro-tein分类
医药卫生引用本文复制引用
丁军颖,桂红,洪燕英,安世栋,丁雪菲,卢幼然,刘清泉..基于耐药基因OPRD2探讨铜绿假单胞菌的临床感染特性[J].解放军医药杂志,2015,27(10):69-71,75,4.基金项目
国家自然科学基金项目( 81373813 ) （ 81373813 ）
国家"重大新药创制"科技重大专项(2013ZX09102026) （2013ZX09102026）
