解放军医药杂志Issue(11)：52-55,4.DOI:10.3969/j.issn.2095-140X.2015.11.015
非小细胞肺癌组织RET融合基因与TYMS基因mRNA的表达及其关系
The mRNA Expressions and Relationship of RET Fusion and of TYMS Genes in Non-small-cell Lung Cancer Tis-sues
摘要
Abstract
Objective To investigate mRNA expressions and relationship of RET fusion and thymidylate syn-thase ( TYMS) genes in non-small-cell lung cancer ( NSCLC) tissues. Methods The mRNA expressions of RET fusion and of TYMS genes in NSCLC tissues of 642 patients were detected using real-time fluorescent quantitative PCR method, and the relationship and its correlation between the expression and clinicopathological features were also analyzed. Results The positive rate of RET fusion gene in NSCLC was 0. 93% (6/642); high mRNA expression of TYMS gene was 63. 55% (408/642). The expressions showed no relationship with gender, age, smoking, tumor size, lymph node metastasis and clinical stages (P>0. 05). The mRNA expressions between RET fusion and TYMS genes showed positive correlation (P<0. 05). Conclusion Thymidylate synthase gene shows low expression level in NSCLC patients with pos-itive RET fusion gene, which may benefit from Pemetrexed of first-line chemotherapy drug.关键词
癌,非小细胞肺/RET 融合基因/胸苷酸合成酶/病理学,分子/基因表达调控,肿瘤Key words
Carcinoma, non-small-cell lung/RET fusion gene/Thymidylate synthetase/Pathology, molecular/Gene expression regulation, neoplastic分类
医药卫生引用本文复制引用
田玉旺,许春伟,邰艳红,高文斌,张立英,王琳,亓岽东,方美玉..非小细胞肺癌组织RET融合基因与TYMS基因mRNA的表达及其关系[J].解放军医药杂志,2015,(11):52-55,4.基金项目
吴阶平医学基金会临床科研专项资助基金项目(320.6750.1360) （320.6750.1360）
浙江省医学科学研究基金项目(2013KBY051) （2013KBY051）
浙江省中医药管理局科研基金(2013ZQ005) （2013ZQ005）
山西省科技攻关基金(20130313021-16) （20130313021-16）
