湖北民族学院学报（医学版）Issue(3)：34-36,3.
基质金属蛋白酶－9在颈动脉斑块易损性中的诊断价值
The Diagnostic Value of Matrix Metalloproteinase-9 in the Vulnerability of Carotid Atherosclerotic Plaque
代统斌 1郑传利 1辛伟 1唐建德 2刘典美 1张明1
作者信息
- 1. 潍坊医学院医学影像学系 山东潍坊261053
- 2. 潍坊医学院附属医院超声科 山东潍坊261053
- 折叠
摘要
Abstract
Objective To expIore the reIationship between the vuInerabiIity of carotid atheroscIe-rotic pIaques in patients with ischemic stroke by two-DimensionaI uItrasound of carotid artery pIaque type and IeveI of joint determination of pIasma matrix metaIIoproteinase-9 (MMP-9). Methods 90 cases of patients with ischemic stroke were randomIy seIected in NeuroIogy, de-pending on the nature of atheroscIerotic pIaques into vuInerabiIity group ( 48 cases) and non-vuInerabIe pIaque group ( 42 cases);another normaI 40 cases in our hospitaI medicaI randomIy seIected center as a controI group;MMP-9 IeveIs were measured in three groups,and correIa-tion anaIysis was made.Results Two-dimensionaI uItrasound can dispIay the stabiIity of carotid atheroscIerotic pIaque.CerebraI infarction with carotid atheroscIerosis group MMP-9 IeveI was significantIy higher (P<0.01);VuInerabIe pIaque group MMP-9 IeveIs were significantIy higher than those of non-vuInerabIe pIaque group ( P<0.01 );reIevant ( r=0.89, P<0.01 ) in patients with ischemic cerebraI infarction between MMP-9 IeveIs and vuInerabiIity of carotid atheroscIe-rotic pIaques.Conclusion MMP-9 is an effective,sensitive and non-invasive biomarkers to as-sess the vuInerabiIity of ischemic stroke carotid atheroscIerotic pIaques.It can aIso be used as an auxiIiary Iaboratory parameters used to assess ischemic stroke risk factors when combined with the two-dimensionaI uItrasound.关键词
颈动脉粥样硬化斑块/基质金属蛋白酶-9/二维超声Key words
carotid atheroscIerotic pIaque/matrix metaIIoproteinase-9/dimensionaI uItrasound分类
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代统斌,郑传利,辛伟,唐建德,刘典美,张明..基质金属蛋白酶－9在颈动脉斑块易损性中的诊断价值[J].湖北民族学院学报（医学版）,2015,(3):34-36,3.
