郑州大学学报（医学版）Issue(5)：605-609,5.DOI:10.3969/j.issn.1671-6825.2013.05.009
胶质瘤组织中 CPEB4和 Bcl-xL 的表达及预后影响因素分析
Expressions of CPEB4 and Bcl-xL in glioma tissue and the related prog-nostic factors analysis
摘要
Abstract
Aim:To detect the expressions of cytoplasmic polyadenylation element-binding protein 4 ( CPEB4 ) and Bcl-xL in glioma tissue , and investigate the prognostic factors of patients with glioma .Methods:The expressions of CPEB 4 and Bcl-xL in 165 cases of different grade glioma (69 cases of low grade , and 96 cases of high grade ) tissue were detected by immunohistochemical staining .The univariate and multivariate logistic regression was used to analyze the relationship between the expressions of CPEB 4 and Bcl-xL and the clinical factors with 3-year survival rate of the patients .Results:The positive expression rates of CPEB 4 and Bcl-xL in high grade glioma were significantly higher than those in low grade glioma(χ2 =28.971 and 17.601,P<0.05).The univariate logistic regression analysis screened 8 related factors(P<0.05),among which, multivariate logistic regression analysis further screened 6 independent factors including preoperative KPS score, the resection extent , postoperative chemotherapy , malignant degree and the expressions of CPEB 4 and Bcl-xL (P<0.05).Conclusion:The expressions of CPEB4 and Bcl-xL are related with the malignant degree of glioma .The pre-operative KPS score , the resection extent , postoperative chemotherapy , malignant degree and the expressions of CPEB 4 and Bcl-xL can be regarded as important prognostic indicators for patients with glioma .关键词
胶质瘤/胞质多聚腺苷酸化成分结合蛋白4/Bcl-xL/预后Key words
glioma/cytoplasmic polyadenylation element-binding protein 4/Bcl-xL/prognosis分类
医药卫生引用本文复制引用
梁博,王新军,周少龙..胶质瘤组织中 CPEB4和 Bcl-xL 的表达及预后影响因素分析[J].郑州大学学报（医学版）,2013,(5):605-609,5.基金项目
河南省教育厅重点攻关基金资助项目092102310090 （）
