郑州大学学报（医学版）Issue(5)：609-612,4.DOI:10.3969/j.issn.1671-6825.2013.05.010
高脂血症对大鼠脑组织 MMP-2表达及新生血管的影响
Effects of hyperlipidemia on MMP-2 expression and new vessels in brain tissue of rats
摘要
Abstract
Aim:To observe the effects of hyperlipidemia on matrix metalloproteinase-2 ( MMP-2 ) expression and the new vessels in brain tissue of rats .Methods:Experimental rats were divided into normal control group and hyperlipidemia group with 10 rats in each group .The concentration of VEGF in serum of the two groups was determined by ELISA .The ex-pressions of MMP-2, intercellular adhesion molecule-1(ICAM-1), CD34, and vascular endothelial growth factor (VEGF) in rat brain tissue were detected by immunohistochemistry .The pathological change in cortex of rats was observed after HE staining.Results:The contents of TC, TG,LDL-C and VEGF in serum of hyperlipidemia group were higher than those of normal control group(t=12.772, 25.705, 38.141, 15.879,P<0.001), while HDL-C was lower (t =35.959,P<0.001).The expressions of MMP-2, ICAM-1, CD34 and VEGF in brain tissue of hyperlipidemia group were higher than those of normal control group (t=25.546, 12.954, 8.685, 11.996,P<0.001).Conclusion:Hyperlipidemia could in-duce the expression of MMP-2 and generate more new blood vessels in brain .关键词
高脂血症/新生血管/基质金属蛋白酶-2/细胞间黏附分子-1/CD34/血管内皮生长因子/大鼠Key words
hyperlipidemia/new vessel/matrix metalloproteinase-2/intercellular adhesion molecule-1/CD34/vas-cular endothelial growth factor/rat分类
医药卫生引用本文复制引用
张振强,贾亚泉,宋军营,李澎涛,潘彦舒,王丛笑,吕欢欢..高脂血症对大鼠脑组织 MMP-2表达及新生血管的影响[J].郑州大学学报（医学版）,2013,(5):609-612,4.基金项目
国家科技重大专项基金资助项目2009 ZX09502-014；河南省基础与前沿技术研究基金资助项目122300410026 （）
