郑州大学学报（医学版）Issue(5)：661-663,3.DOI:10.3969/j.issn.1671-6825.2013.05.025
血清 CA19-9和血浆 FIB 水平在良、恶性梗阻性黄疸鉴别诊断中的价值
Differential diagnosis value of serum CA19-9 level combined with plasma FIB level between benign and malignant obstructive jaundice
摘要
Abstract
Aim:To explore the value of serum carbohydrate antigen 19-9(CA19-9) combined with plasma fibrinogen ( FIB) for the differential diagnosis of benign and malignant obstructive jaundice .Methods:A total of 60 benign obstruc-tive jaundice patients and 75 malignant obstructive jaundice patients were subjected to detect the serum CA 19-9 and plasma FIB.The serum CA19-9 was detected via the electrochemical luminescence method .The plasma FIB was detected via the optics method.The diagnostic performance of CA 19-9 and FIB in the benign and malignant obstructive jaundice was evalua-ted with ROC curve .Results:The levels of CA19-9 and FIB of the malignant obstructive jaundice patients were signifi-cantly higher than those of benign patients (Z=7.420,6.862,P<0.05).The AUC(CA19-9) and AUC(FIB) of ROC curve were 0.872 and 0.844,and 95%CI was (0.813-0.931) and (0.777-0.912).When the cut-off point was deter-mined as 35.085 U/mL for CA19-9 and 2.45 g/L for FIB on the basis of highest value of sensitivity and specificity , thesensitivity(95%CI) of CA19-9, FIB, and combined detection were 88.0%(82.5% -93.5%),84.0%(77.8% -90.2%), and 98.7%(98.2% -99.2%).Conclusion: The combined detection of CA19-9 and FIB can improve thesensitivity of differential diagnosis of benign and malignant obstructive jaundice .关键词
糖类抗原19-9/纤维蛋白原/梗阻性黄疸/鉴别诊断Key words
carbohydrate antigen 19-9/fibrinogen/obstructive jaundice/differential diagnosis分类
医药卫生引用本文复制引用
杨万荷,李家群,仝亚林,李林静,李治国,冯百岁..血清 CA19-9和血浆 FIB 水平在良、恶性梗阻性黄疸鉴别诊断中的价值[J].郑州大学学报（医学版）,2013,(5):661-663,3.基金项目
河南省科技攻关计划项目102102310115 （）
