郑州大学学报（医学版）Issue(6)：781-785,5.DOI:10.13705/j.issn.1671-6825.2015.06.013
重复经颅磁刺激对抑郁模型大鼠学习记忆功能及海马 CA3区突触素表达的影响
Effect of rTMS on learning memory abilities and the synaptophysin ex-pression in hippocampus CA 3 of depressed rats
摘要
Abstract
Aim:To investigate the effect of repetitive transcranial magnetic stimulation ( rTMS) on learning and mem-ory abilities, the expression of SYP protein in hippocampus CA3 region of depressed rats.Methods: Forty SD rats were randomly allocated into 4 groups:control group, depression group, rTMS group,and fake stimulation group,10 in each group.Rats in the latter 3 groups were given chronic unpredictable mild stress to establish depression model .rTMS group rats were given 15 Hz rTMS for 3 courses .Sham stimulation group were given only the same number of sound stimulation without electricity and current pulse .Then, Morris water maze test, including place navigation and spatial probe test , were performed to access the rats′learning and memory abilities , and the expression of SYP protein in hippocampus CA 3 was de-tected by immunohistochemistry .Results:There were significant differences in the escape latency ,the swimming time in o-riginal platform quadrant , the swimming distance percentage of total swimming distance in the original platform quadrant , and the expression of SYP protein in hippocampus CA 3 region among the 4 groups ( F =39.608,646.088,198.940, 388.673,P<0.001).Compared with the control group , the escape latency prolonged , the swimming time in original plat-form quadrant shortened , the swimming distance percentage of total swimming distance in the original platform quadrant re -duced, and the expression of SYP protein decreased in depression group and fake stimulation group (P<0.05).Compared with the depression group and fake stimulation group , the indexes mentioned above were improved ( P<0.05 ) in rTMS group.Conclusion:rTMS can improve the learning and memory abilities of depressed rats , the possible mechanism is in-creasing the expression of SYP in hippocampal CA 3 region.关键词
抑郁症/重复经颅磁刺激/学习记忆功能/突触素Key words
depression/repetitive transcranial magnetic stimulation/learning and memory ability/synaptophysin分类
医药卫生引用本文复制引用
欧阳华,白冰,赵琳,任慧聪,张朝辉..重复经颅磁刺激对抑郁模型大鼠学习记忆功能及海马 CA3区突触素表达的影响[J].郑州大学学报（医学版）,2015,(6):781-785,5.基金项目
河南省医学科技攻关项目201203071 （）
