郑州大学学报（医学版）Issue(6)：843-846,4.DOI:10.13705/j.issn.1671-6825.2015.06.028
TEKT3在特发性弱精子症患者精子中的表达
Expression of TEKT3 in spermatozoa of idiopathic asthenozoospermia pa-tients
摘要
Abstract
Aim:To investigate the function of TEKT 3 protein in the pathogenesis of patients with idiopathic astheno-zoospermia .Methods:Semen samples were collected from 35 normal controls and 35 idiopathic asthenozoospermia patients and purified using Percoll discontinuous density gradients , then the expression of TEKT 3 mRNA and TEKT3 protein were detected by RT-PCR and Western blot .Results: Compared with normal controls , the expressions of TEKT3 mRNA and protein in spermatozoa of idiopathic asthenozoospermia group were obviously decreased (t=9.610,10.090,P<0.001). Correlation analysis revealed that the expressions of TEKT 3 mRNA and protein were positively correlated with spermatozoa progressive motility(r=0.684,P=0.001;r=0.483,P=0.013).Conclusion: The reduced expression of TEKT3 may play an important role in the pathogenesis of idiopathic asthenozoospermia .关键词
TEKT3/特发性弱精子症/精子前向运动能力Key words
TEKT3/idiopathic asthenozoospermia/sperm progressive motility分类
医药卫生引用本文复制引用
李玉山,陈河涛,杨夕阳,王全先,刘军杰,王琳凯,苏彦华,孙琳..TEKT3在特发性弱精子症患者精子中的表达[J].郑州大学学报（医学版）,2015,(6):843-846,4.基金项目
郑州市科技攻关计划项目112PPTSF318-7 （）
