化工进展Issue(z1)：116-120,5.
有机相中脂肪酶催化转酯化反应动力学拆分左旋帕罗醇
Kinetic resolution of transesterification reaction of trans-paroxol catalyzed by lipase in organic media
摘要
Abstract
The kinetic resolution of transesterification reaction of trans-paroxol catalyzed by lipase was studied in organic media.The influence factors including enzyme source,solvent,acyl donor, temperature,substrate and the molar ratio of substrate with acyl donor were researched.The optimal conditions were obtained as following:Acetonitrile as solvent, viny acetate as acyl donor,concentration of substrate of 40mmol/L,the molar ratio substrate with acyl donor of 1∶8 and reaction temperature 30℃.The conversion,the ees and the E value reached 48.1%,53.3%and 6.20 under the optimal conditions after 8h.关键词
有机相/酶/转酯化/动力学拆分/左旋帕罗醇Key words
organic media/enzyme/transesterification/kinetic resolution/trans-paroxol引用本文复制引用
贾义刚,刘维明,倪潇,黄和,胡燚..有机相中脂肪酶催化转酯化反应动力学拆分左旋帕罗醇[J].化工进展,2015,(z1):116-120,5.基金项目
国家高技术发展计划项目(2011AA02A209)。 （2011AA02A209）
