化工学报2015，Vol.66Issue(12)：4843-4849,7.DOI:10.11949/j.issn.0438-1157.20151013
2-氯-5-三氟甲基吡啶和3-三氟甲基吡啶的制备
Production of 2-chloro-5-trifluoromethylpyridine and 3-trifluoromethylpyridine
摘要
Abstract
2-Chloro-5-trifluoromethylpyridine and 3-trifluoromethylpyridine are produced byβ-picoline reacting with chlorine and hydrogen fluoride in a fluidized-bed reactor. The total yield of 2-chloro-5- trifluoromethylpyridine and 3-trifluoromethylpyridine reaches 66.6% over the CrO-Al catalyst at a space velocity of 288 h-1 and temperature of 300℃. The reactivity of the deactivated catalysts is recovered after regeneration at 350℃with mixed gas of nitrogen and air at volume ratio of 1:1. The total yield is around 66% with regenerated catalysts under the condition of 288 h-1 and 300℃. According to the reaction result, the mechanism of one-step chlorofluorination reaction is proposed, dehydrochlorination-condensation of intermediate products accounted for coking. The results of BET, TG and NH3-TPD characterizations indicate that the deactivation of the catalysts is caused by the carbonaceous by-products which cover the surface and pores of the catalyst.关键词
3-甲基吡啶/2-氯5-三氟甲基吡啶/3-三氟甲基吡啶/流化床/催化剂/活性/再生Key words
2-chloro-5-trifluoromethylpyridine/3-trifluoromethylpyridine/β-picoline/fluidized-bed/catalyst/reactivity/regeneration分类
化学化工引用本文复制引用
董青青,于万金,胡猛,林胜达,刘武灿,张建君,程党国,陈丰秋..2-氯-5-三氟甲基吡啶和3-三氟甲基吡啶的制备[J].化工学报,2015,66(12):4843-4849,7.基金项目
浙江省博士后科研择优资助项目(BSH1402061). supported by the Postdoctor Foundation of Zhejiang (BSH1402061). （BSH1402061）
