湖南中医药大学学报Issue(11)：10-12,17,4.DOI:10.3969/j.issn.1674-070X.2015.11.003
白术七物颗粒对气阴两虚型STC大鼠结肠组织NSE的影响
Effects of BaizhuQiwu Granules on the NSE in Colon Tissue of STC Rats with Deficiency of both Qi and Yin Syndrome
摘要
Abstract
〔Abstract〕 Objective To study the effect of Baizhu Qiwu Granules on neuron specific enolase (NSE) in colonic tissues of colon slow transit constipation rats with deficiency of both Qi and Yin syndrome and to explore its mechanism of action. Methods 60 SD rats were randomly divided into normal group, model group and treatment group, 20 rats in each group. The rats in normal group were given isovolumetric and isotonic normal saline in subcutaneous injections and the remaining rats in model and treatment groups were daily subcutaneous injection of 2.5mg/kg·d of morphine hydrochloride for total 45 days, and at the same time administered with Qingpi (18 g), Zhike (18 g) and Fuzi (15 g) to build thecolon slow transit constipation model rats with deficiency of both Qi and Yin syndrome.After establishing the models successfully, the rats in each group are given the corresponding drug treatment once daily for 14 days. At the final injection,the level of NSE in colonic tissues of rats was measured. Results There was no significant difference in the dry weight of the feces of the rats in each group before building. After modeling, the dry weight of the feces of rats in the model group and the treatment group were significantly decreased compared with the normal group, the differences have statistical significance (P<0.01). The rate of intestinal charcoal propulsion in the model group and the treatment group were significantly decreased compared with the normal group, the differences have statistical significance (P<0.01). The content level of NSE in colon tissue of rats in the model group and treatment group was increased compared to the normal group, the differences have statistical significance (P <0.05). The content level of NSE in colon tissue of rats in the treatment group was decreased compared to the normal group, the differences have statistical significance (P<0.05). Conclusion Baizhu Qiwu Granules can effectively treat both Qi and Yin type of colonic slow transit constipation,which may be related with the elevated NSE level.关键词
结肠慢传输型便秘/白术七物颗粒/气阴两虚型/血管活性肠肽/NSEKey words
slow transit constipation/Baizhu Qiwu Granules/deficiency of both Qi and Yin type/vasoactive intestinal peptide/NSE分类
医药卫生引用本文复制引用
谭蕊,林仁敬,何永恒..白术七物颗粒对气阴两虚型STC大鼠结肠组织NSE的影响[J].湖南中医药大学学报,2015,(11):10-12,17,4.基金项目
国家自然科学基金资助项目（81302977）。 （）
