基础医学与临床Issue(2)：187-190,4.
Intermedin1-53抑制血管紧张素Ⅱ诱导的大鼠心肌成纤维细胞合成胶原
Intermedin1-53 inhibits collagen synthesis induced by angiotensinⅡin cadiac fibroblasts of rats
摘要
Abstract
Objective To investigate collagen metabolism modulation of Intermedin 1-53 ( IMD1-53 ) on angiotensin Ⅱ( AngⅡ)-induced rat cardiac fibroblasts .Methods SD neonatal rat cardiac fibroblasts were cultured and divided them into control group, AngⅡ +different concentrations IMD1-53 groups.ⅠandⅢcollagen expression in cardiac fibroblasts were measured by Westem blot , IMD1-53 receptor-like receptor ( calcitonin receptor-like receptor , CRLR) and transforming growth factor-β( TGF-β) mRNA expression were exammed by real-time PCR.Results IMD1-53 significantly inhibited AngⅡ-induced collagen synthesis in cardiac fibroblasts , and this effect was more ob-vious with the increase of IMD 1-53 ( P<0.01 ,P<0.05 ) .Similar phenomenon was recorded in TGF-βexpression in cardiac fibroblasts ( P<0.05 ) .Conclusions IMD1-53 inhibited collagen synthetic in cardiac fibrosis induced by AngⅡ, down-regulated TGF-βexpression.These may relate to IMD1-53 anti myocardial fibrosis.关键词
Intermedin1-53/心肌成纤维细胞/血管紧张素Ⅱ/转化生长因子-βKey words
Intermedin1-53/cardiac fibroblast/angiotensin Ⅱ/transforming growth factor-β分类
医药卫生引用本文复制引用
孔祥权,睢燕,蒋静涵,许守明,章辉..Intermedin1-53抑制血管紧张素Ⅱ诱导的大鼠心肌成纤维细胞合成胶原[J].基础医学与临床,2015,(2):187-190,4.基金项目
安徽省教育厅自然科学基金（ KJ2013 Z334）；皖南医学院重点科研培育项目 （）
