基础医学与临床Issue(9)：1176-1181,6.
H3 K27 me3去甲基化酶Jmjd3调节胎鼠肺上皮细胞增殖和分化
H3 K27 me3 demethylase Jmjd3 regulates proliferation and differentiation of embryonal lung epithelia of mice
摘要
Abstract
Objective To investigate the role of H3K27me3 demethylase Jmjd3(KDM6B) during the development of lung in embryonal mice .Methods Jmjd3 knockout embryos of E 19.5 mice were examined by HE , PAS and immnohistochemistry assays .Results The developmental defects of the lung of Jmjd 3 heterozygous ( Jmjd3 +/-) embryos were mild is compared to Jmjd3 +/+embryos.However, Jmjd3 -/-mice suffered from the severe hypoplasia of lung tissue .Differentiated defects of ciliated cell , Clara cell , type Ⅰ and Ⅱ alveolar epithelial cells were ob-served in Jmjd3 -/-embryos.The index of cell proliferation was increased in Jmjd3 -/-embryos as compared to wildtype and Jmjd3 +/- embryos.No difference in apoptosis profile was found in these embryos .Conclusions Jmjd3 is essential for proliferation and differentiation of embryonal lung epithelia of mice .关键词
Jmjd3/肺上皮细胞/增殖/分化Key words
Jmjd3/epithelia of lung/proliferation/differentiation分类
生物科学引用本文复制引用
冯欢,张超,张哲恺,章铭,张丰..H3 K27 me3去甲基化酶Jmjd3调节胎鼠肺上皮细胞增殖和分化[J].基础医学与临床,2015,(9):1176-1181,6.基金项目
国家自然科学基金 （）
