基础医学与临床Issue(9)：1252-1255,4.
肛管直肠恶性黑色素瘤7例临床病理学分析
Anorectal malignant melanoma:a clinicopathological analysis of seven cases
摘要
Abstract
Objective To investigate the clinical and pathological features of anorectal malignant melanoma ( AMM) .Methods The clinical pathological and follow-up data of 7 cases of anorectal malignant melanoma were collected.The clinical and histopathological features and immunophenotype were analyzed .Results Among the 7 cases, 5 cases were female, 2 cases were male, aged 50-68 years, the average was 61 years.The tumors located in the lower rectum in 1 cases, 2 cases of teeth near the line , 4 cases of anal anus .The structure and morphology of the cancer cells were diverse .The organizational structures were mainly diffuse , focal and acinar .The cellular morphologies were mainly epithelioid , spindle and lymphocyte like .And the results of IHC showed the expression of the following three markers, vimentin, S-100 and HMB45, were strongly positive in cancer cells.However, the expression of CK , EMA and LCA were negative .And 2 cases of CEA expression were positive , LI Ki-67 was 20%-50%.Conclusions Anorectal malignant melanoma is one kind of rare malignant tumor and its characteristic morphology , immunophenotype could be helpful for diagnosis and differential diagnosis .关键词
肛管直肠/恶性黑色素瘤/临床病理特征/免疫组化/鉴别诊断Key words
anorectal malignant melanoma/clinicopathologic features/immunohistochemistry/differential diagnosis分类
医药卫生引用本文复制引用
李钢琴,袁修学,夏小丽,龚立刚,袁静萍..肛管直肠恶性黑色素瘤7例临床病理学分析[J].基础医学与临床,2015,(9):1252-1255,4.基金项目
湖北省自然科学基金 （）
