井冈山大学学报（自然科学版）Issue(3)：83-87,5.DOI:10.3969/j.issn.1674-8085.2013.03.020
白芍总苷辅助治疗类风湿关节炎的Meta分析
EFFICACY AND SAFETY OF TOTAL GLUCOSIDES OF PAEONY FOR RHEUMATOID ARTHRITIS:A META-ANALYSIS
摘要
Abstract
Objective: To evaluate the efficacy and safety of total glucosides of paeony (TGP) for rheumatoid arthritis (RA). Methods: Searching was conducted in the following databases: PubMed, EMbase, Cochrane Library, CNKI, VIP and WanFang from their establishment to June 2012. Randomised controlled trials involving TGP for patients with RA were collected. The quality of included studies was evaluated and Meta-analysis was performed. According to the Cochrane methods, valid data were picked up to be meta-analyzed by RevMan5.0 software. Results: A total of 15 studies including 1130 patients were enrolled. The meta-analysis indicated efficacy of TGP group was significant superior to that of control group after a period of 12 weeks treatment [RR=1.13, 95%CI (1.04, 1.23), P<0.01]. But no significant difference after 24 weeks treatment was observed [RR=1.13, 95%CI (0.79, 1.64), P>0.05]. Side effect rates showed statistical significance between the two groups [RR=0.66, 95%CI (0.54, 0.81), P<0.01]. Conclusion:An adjuvant treatment with TGP for RA patients could significantly improve the efficacy in a period of 12 weeks. And it could reduce the side effects especially liver toxicity of other drugs. However, high quality RCTs with larger samples are needed for a further analysis.关键词
白芍总苷/类风湿关节炎/Meta分析/系统评价/有效性Key words
total glucosides of paeony/rheumatoid arthritis/meta-analysis/systematic review/efficacy分类
医药卫生引用本文复制引用
郭小靖,李升,黄玉珊..白芍总苷辅助治疗类风湿关节炎的Meta分析[J].井冈山大学学报（自然科学版）,2013,(3):83-87,5.基金项目
江西省社科规划项目 （）
