摘要
Abstract
Objective To observe the clinical effect of compound bismuth and magnesium combined with quadruple therapy in eradication of Helicobacter pylori(Hp). Methods 132 patients with chronic gastritis or peptic ulcer combined with Hp infection in Pingdingshan second people’s hospital from January 2013 to December 2014 were selected.They were randomly divided into treatment group and control group,each group was 66 cases.The treatment group was given stomach bismuth magnesian particle,lansoprazole,amoxicillin and clarithromycin. Control group was given colloidal bis-muth pectin,lansoprazole,amoxicillin and clarithromycin.Two groups were oral treated for 14 days.After treatment,the eradication rate of Hp was compared by reviewing 14C- urea breath test.The adverse effect in two groups was observed during treatment. Results The eradication rate of Hp in treatment group was 93.9%(62/66),in control group was 90.9%(60/66),the difference was significant between two groups (P>0.05).The digestive tract adverse effect rate in treatment group was 3.0%,which was significantly lower than 13.6%of control group,and the difference was statistical significance (P<0.05).There was no serious adverse effect occurred between two groups. Conclusion Compound bismuth and magne-sium combined with quadruple therapy has exact effect in eradication of Hp,and the occurrence of adverse effect rate lower than compound colloidal bismuth pectin combined with quadruple therapy.It has a higher safety and worth popu-larizing in clinical.关键词
胃铋镁颗粒/四联疗法/幽门螺杆菌/慢性胃炎/消化性溃疡Key words
Stomach bismuth magnesian particle/Quadruple therapy/Helicobacter pylori/Chronic Gastritis/Peptic Ulcer分类
医药卫生
