中国健康心理学杂志Issue(12)：1764-1767,1768,5.DOI:10.13342/j.cnki.cjhp.2015.12.002
认知行为疗法合并帕罗西汀治疗重度抑郁的对照研究
Effects of Cognitive-behavior Therapy Combined with Paroxetine in the Treatment of Severe Depression
王东明 1胡明江 2吴科斌 1张润荣 2邱小英3
作者信息
- 1. 中国.福建医科大学附属龙岩第一医院精神病学教研室 福建龙岩 364000
- 2. 福建省龙岩市第三医院心身科
- 3. 福建省龙岩市第三医院心身科
- 折叠
摘要
Abstract
Objective:To evaluate clinical efficacy and safety of cognitive -behavior therapy com-bined with paroxetine in the treatment of severe depression .Mte hods: 66 inpatients and outpatients who met ICD-10 diagnostic criteria for severe depression were randomized to two groups .The research group ( n=34 ) received Cognitive-Behavior Therapy combined with paroxetine and the control group ( n=32 ) received paroxetine for 12 weeks.Clinical efficacy and adverse reaction were assessed with the Hamilton Depression Scale ( HAMD ) , Hamilton Anxiety Scale ( HAMA ) , Clinical Global Impression ( CGI ) and Treatment Emergent Symptom Scale (TESS)before treatment and at the end of the 2nd,4th,6th,8th,12th week.Results:Before treatment,there were no significant differences in the scores of both HAMD and HAMA between the two groups .After 12weeks treatment ,the scores of HAMD and HAMA in both groups were lower than those before pretreatment ( The research group t=40 .26 ,-27 .29;P<0 .01;the control group t=19.11,70.85;P<0.01).At the end of the 6th,8th,12th week,the scores of both HAMD and HAMA were lower in the research group than in the control group ( t =-2.82,-2.84,-3.41,-2.14,-3.01,-3.34;P<0.05).The effective rate was higher in the research group than in the control group (χ2=4.799,P<0.05).The adverse reaction was lower in the research group than in the control group (χ2 =4.855,P<0.05).Conclusion:Cognitive-behavior therapy combined with paroxetine has a better effica-cy and higher safety in the treatment of severe depression .关键词
认知行为疗法/帕罗西汀/重度抑郁/临床试验Key words
Cognitive-behavior therapy/Paroxetine/Severe depression/Clinical trial分类
医药卫生引用本文复制引用
王东明,胡明江,吴科斌,张润荣,邱小英..认知行为疗法合并帕罗西汀治疗重度抑郁的对照研究[J].中国健康心理学杂志,2015,(12):1764-1767,1768,5.
