军事医学Issue(9)：664-667,4.DOI:10.7644/j.issn.1674-9960.2015.09.004
高功率微波对大鼠脑组织氧化应激的影响
Oxidative stress effect of HPM on brain of rats
摘要
Abstract
Objective To investigate the adverse effect of different doses of high power microwave(HPM) irradiation on oxidative stress in the brain of Wistar rats in order to contribute to establishing an animal model to evaluate protective agents which will be used for protection against microwave radiation.Methods Eighty male Wistar rats were randomly divided into 16 groups according to factor analysis.The average power density was 0,10,30 and 100 mW/cm2 and the sampling time was 6 h,1,3 and 7 d .The duration of exposure was 6 minutes for each radiation group.After exposure, the rats were sacrificed at each sampling time.Colorimetric method was used to measure the content of malondialdehyde(MDA) and protein carbonyl, the activity of GSH-px, SOD and CAT.Results The content of MDA and protein carbonyl of each radiation group was increased with the radiation dose, but decreased with the sampling time prolonged.The activity of superoxide dismutast(SOD),glutathion peroxidase(GSH-px) and catalase(CAT) in each radiation group was decreased with the radiation dose increased, and with the sampling time prolonged, but increased later.Conclusion Microwave radiation can cause oxidative stress in rats brain, as shown by the oxidative damage of lipid and protein and the decrease in the activity of antioxidant enzymes.Besides, the effect also depends on the radiation dose and sampling time.关键词
高功率微波辐射/脑组织/氧化应激/辐射剂量/丙二醛/超氧化物歧化酶Key words
high power microwave/brain/oxidative stress/radiation dosage/malondialdehyde/superoxide dismutase分类
医药卫生引用本文复制引用
郑文,张庆林,王长振,彭瑞云,王水明,王丽峰,邹勇,李海娟,智维佳,胡向军..高功率微波对大鼠脑组织氧化应激的影响[J].军事医学,2015,(9):664-667,4.基金项目
国家重大专项资助课题 （）
