军事医学Issue(10)：805-807,3.DOI:10.7644/j.issn.1674-9960.2015.10.018
SENP1的生理功能研究进展
Physiologic function of SENP1:research progress
摘要
Abstract
Post-transcriptional regulation of prokaryotes is of pivotal importance to the quality control and stability main -tenance of multiple proteins .The ubiquitin and ubiquitin-like proteins-mediated modifications have widely participated in the manipulation of cell cycle control , subcellular localization and cellular metabolisms .Typical ubiquitin like proteins (UBLs) are ubiquitin,SUMO,Nedd8 and FAT10.Recently, the dynamic regulation mechanisms between sumoylation and de-sumoylation have become the cutting edge in the era of ubiquitin-like modifications.In this review, we briefly summa-rized the entire SUMO-mediated modification systems and the intricate balance regulation .We also discussed the counter acting star molecule SENP1 and its relationship with tumor initiation and progression ,immunological regulation and develop-mental homeostasis .关键词
SUMO/SENP1/肿瘤生成/免疫调控/发育稳态Key words
SUMO/SENP1/tumorigenesis/immunological regulation/developmental homeostasis分类
生物科学引用本文复制引用
王嵘..SENP1的生理功能研究进展[J].军事医学,2015,(10):805-807,3.基金项目
国家自然科学基金资助项目 （）
