解放军医学院学报Issue(2)：172-174,178,4.DOI:10.3969/j.issn.2095-5227.2013.02.028
厄贝沙坦预处理对心肌缺血再灌注损伤的影响
Effect of irbesartan pretreatment on myocardial ischemia/reperfusion injury in rats
摘要
Abstract
Objective To study the effect of irbesartan pretreatment on myocardial ischemia/reperfusion(I/R) injury in rats and its possible mechanism. Methods Thirty-eight healthy male SD rats were randomly divided into sham group(group A), I/R injury group(group B), and irbesartan pretreatment group(group C). A rat myocardial I/R injury model was established. Myocardial tissue samples were stained with TTC to observe the myocardial infarction size and myocardial cell structure. Serum malondialdehyde(MDA) concentration was measured by colorimetry, TNI content in rats was assayed by biochemical test, and serum tumor necrosis factor(TNF-α) and interleukin-6(IL-6) concentrations were measured by ELISA. Results The myocardial infarction size was smaller, the inflammatory cell infiltration was milder, the myocardial cell structure was better, and the serum MDA TNI, IL-6 and TNF-αconcentrations were lower in group C than in group B(P<0.05, P<0.01). Conclusion Irbesartan pretreatment protects myocardium against I/R injury possibly by reducing the synthesis or releasing of inflammation factors.关键词
厄贝沙坦/心肌缺血再灌注/炎症因子/大鼠Key words
irbesartan/myocardial ischemia reperfusion/inflammatory factor/rat分类
医药卫生引用本文复制引用
徐敬娟,赵凤琴..厄贝沙坦预处理对心肌缺血再灌注损伤的影响[J].解放军医学院学报,2013,(2):172-174,178,4.
