解放军医学院学报Issue(4)：325-326,337,3.
拉帕替尼治疗HER-2阳性晚期乳腺癌的疗效观察
Therapeutic effect of lapatinib on HER-2 positive advanced breast cancer
韩春 1游俊浩 1井方方 1令狐锐霞 1高萍 1杨俊兰1
作者信息
- 1. 解放军总医院 肿瘤内科，北京 100853
- 折叠
摘要
Abstract
Objective To study the therapeutic effect of lapatinib on HER-2 positive advanced breast cancer and its toxic and side effect. Methods Clinical data about 23 patients with HER-2 positive advanced breast cancer who received lapatinib treatment in our hospital from December 2007 to December 2011 were analyzed. Time of disease progress, effective therapeutic rate, beneficial clinical rate, and toxic and side effect were observed. Results The total effective rate and beneficial clinical rate of lapatinib was 65.2%and 86.9%, respectively, for HER-2 positive advanced breast cancer. The time from median to disease progress was 11.9 months. The main toxic reactions to lapatinib were diarrhea, hand-foot syndrome and oral mucositis. No grades 3-4 toxics reactions occurred. Conclusion Lapatinib is an effective and well-tolerated molecular targeting drug for HER-2 positive advanced breast cancer.关键词
拉帕替尼/HER-2阳性/乳腺癌/分子靶向治疗Key words
lapatinib/HER-2 positive/breast cancer/molecular targeting therapy分类
医药卫生引用本文复制引用
韩春,游俊浩,井方方,令狐锐霞,高萍,杨俊兰..拉帕替尼治疗HER-2阳性晚期乳腺癌的疗效观察[J].解放军医学院学报,2013,(4):325-326,337,3.
