解放军医学院学报Issue(5)：516-518,3.DOI:10.3969/j.issn.2095-5227.2013.05.029
寻常型银屑病皮损处ASC和caspase-1的表达
Expressions of apoptosis-associated speck-like protein and caspase-1 in psoriasis vulgaris
胡坚 1杨闰平 1李恒进 1赵华1
作者信息
- 1. 解放军总医院 皮肤科，北京 100853
- 折叠
摘要
Abstract
Objective To study the role of apoptosis-associated speck-like protein (ASC) and caspase-1 in pathogenesis of psoriasis vulgaris. Methods Expression and distribution of ASC and caspase-1 in 30 psoriasis vulgaris patients were detected by immunohistochemistry. Results The ASC was intensely stained and expressed in cytoplasm and nuclei of psoriasis vulgaris patients and mainly expressed in middle and lower epidermis of normal persons. The caspase-1 was weakly stained and expressed in cytoplasm and full epidermis of psoriasis vulgaris patients and in basal and lower spinous cells of normal persons(t=49, 55, respectively, P<0.01). Conclusion ASC and caspase-1 play a significant role in the inflammation of psoriasis vulgarpsoriasis.关键词
凋亡相关斑点样蛋白/半胱氨酸蛋白酶-1/银屑病Key words
apoptosis-associated speck-like protein/caspase-1/psoriasis分类
医药卫生引用本文复制引用
胡坚,杨闰平,李恒进,赵华..寻常型银屑病皮损处ASC和caspase-1的表达[J].解放军医学院学报,2013,(5):516-518,3.
