摘要
Abstract
Objective To study the effect of pancreaticβ-cell function on glucose metabolism in middle-aged and elderly subjects. Methods Middle-aged and elderly subjects for diabetes mellitus (DM) screening in our hospital from May 2005 to May 2007 were included in this study. Their glucose metabolism was tested by OGTT at the dose of 75g. The subjects were divided into normal glucose tolerance (NGT) group, impaired glucose tolerance (IGR) group and newly diagnosed DM group according to their OGTT. Their pancreatic β-cell function and insulin resistance were assessed, respectively, according to the HBCI/IR and HOMA-IR. Results A total of 756 subjects were included in this study. HBCI/IR showed that the glucose metabolism decreased gradually from NGT to IGR and from IGR to DM and the insulin resistance increased gradually (P<0.001). Univariate linear regression analysis revealed that the HBCI/IR was closely related with glucose metabolism (β=-10.0, 95%CI:-12.6 and-7.3, P < 0.001). Multivariate linear regression analysis displayed that the pancreaticβ-cell function was an important factor for glucose metabolism in middle-aged and elderly subjects after adjustment for sex, age, BMI, SBP, TG, HDL-C and HOMA-IR (β=-0.003, 95%CI:-0.006 and 0.000;P<0.05). Conclusion Pancreaticβ-cell function is an important factor for glucose metabolism in middle-aged and elderly subjects.关键词
中老年/糖代谢状态/胰岛β细胞功能Key words
middle and old age/glucose metabolism status/islet β cell function分类
医药卫生
