解放军医学院学报Issue(7)：737-739,3.DOI:10.3969/j.issn.2095-5227.2013.07.022
乌司他丁治疗急性呼吸窘迫综合征效果的荟萃分析
Effect of ulinastatin on acute respiratory distress syndrome:A meta-analysis
摘要
Abstract
Objective To assess the effect of ulinastatin on acute respiratory distress syndrome (ARDS). Methods A meta-analysis was performed for the clinical trials on ulinastatin in treatment of ARDS covered in PubMed, Embase, CBMdisk, CNKI and Wanfang Database before May 2012 with the software of ReviewManager4.2 on Cochrane Cooperation Network. The curative effect indexes of ulinastatin included respiratory frequency, PaO2/FiO2, PaCO2 and mortality. Results Meta analysis showed that the mean respiratory frequency and mortality were lower whereas the mean PaCO2 and PaO2/FiO2 were higher in ulinastatin treatment group than in control group 7 days after ulinastatin treatment (WMD=-5.74, P=0.003;RR=0.62, P=0.04;WMD=4.78, P<0.000 01;WMD=59.94, P<0.000 01). Conclusion Ulinastatin can significantly improve the pulmonary ventilation and reduce the mortality of ARDS patients.关键词
乌司他丁/急性呼吸窘迫综合征/Meta分析Key words
ulinastatin/respiratory distress syndrome/meta analysis分类
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..乌司他丁治疗急性呼吸窘迫综合征效果的荟萃分析[J].解放军医学院学报,2013,(7):737-739,3.
