解放军医学院学报Issue(8)：820-822,853,4.DOI:10.3969/j.issn.2095-5227.2013.08.009
骨性关节炎患者关节滑液中结合珠蛋白水平与病情严重程度的相关性
Correlation between haptoglobin level in synovial fluid and severity of knee osteoarthritis
廖伟雄 1李众利 1王杰 2王鸿丽 2傅仰木 1白晓伟1
作者信息
- 1. 解放军总医院 骨科，北京 100853
- 2. 国家生物医学分析中心，北京 100850
- 折叠
摘要
Abstract
Objective To study the correlation between haptoblobin (Hp) level in synovial fluid (SF) and severity of osteoarthritis (OA) and the mechanism of Hp underlying the pathogenesis of OA. Methods Forty-one arthroscopy-confirmed knee OA patients and 18 non-OA patients (16 with meniscus injury and 2 with discoid meniscus but without significant cartilage injury) admitted to our hospital from July 2011 to February 2012 were included in this study. Their SF was collected. The OA patients were classified according to the Outerbridge cartilage scoring scale and their HSS knee scores were recorded. Hp levels in SF were measured by ELISA and compared in OA patients at different severity. Results The Hp level in SF was significantly higher in OA patients than in non-OA patients (23.04±13.19μg/ml vs 7.32±3.76μg/ml, P<0.001) and negatively correlated with the knee HSS score in OA patients (r=-0.768, P<0.001). Conclusion Hp level in SF is positively correlated with the severity of OA. Measurement of Hp level in SF is of great importance for the early diagnosis and effective prevention and treatment of OA.关键词
骨性关节炎/关节滑液/酶联免疫吸附试验/结合珠蛋白Key words
osteoarthritis/synovial fluid/enzyme-linked immunosorbent assay/haptoglobin分类
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廖伟雄,李众利,王杰,王鸿丽,傅仰木,白晓伟..骨性关节炎患者关节滑液中结合珠蛋白水平与病情严重程度的相关性[J].解放军医学院学报,2013,(8):820-822,853,4.
