解放军医学院学报Issue(8)：880-882,3.DOI:10.3969/j.issn.2095-5227.2013.08.029
绞股蓝多糖对四氯化碳急性肝损伤的保护作用
Protective effect of gynostemma pentaphyllum makino polysaccharide on carbon tetrachloride-induced liver injury
摘要
Abstract
Objective To study the protective effect of gynostemma pentaphyllum makino polysaccharide (PGP) on carbon tetrachloride (CCl4)-induced liver injury in mice. Methods Forty-eight male Kunming mice were randomly divided into control group, CCl4 group injury group, and PGP protection group (3 mg/kg, 6 mg/kg, 12 mg/kg and 18 mg/kg), 8 in each group. A mouse acute liver injury model was established by abdominal injection with CCl4. Pathological changes in liver tissue sections were observed. Serum ALT and AST activities were measured. Results The pathological liver tissue changes were significantly less whereas the serum ALT and AST activities were significantly lower in PGP protection group than in CCl4 group and injury group(P<0.05). The protective effect of PGP on CCl4-induced liver injury was the best at the dose of 6 mg/kg. Conclusion PGP can effectively protect liver against CCl4-induced acute injury, which may be related with its anti-oxidizing, cell membrane stabilizing and lysosomal membrane preventing liver cell necrosis effects.关键词
绞股蓝多糖/四氯化碳/肝损伤/A丙氨酸氨基转移酶/天冬氨酸氨基转移酶Key words
gynostemma pentaphyllum polysaccharide/carbon tetrachloride/hepatic injury/alanine aminotransferase/aspartate aminotransferase分类
医药卫生引用本文复制引用
杨倚天,于淼,李江冰,吴海建,龚秀,辛华,李霞,陈为,房星宇,宋海洋..绞股蓝多糖对四氯化碳急性肝损伤的保护作用[J].解放军医学院学报,2013,(8):880-882,3.基金项目
山东大学大学生创新性实验计划资助项目 （）
