解放军医学院学报Issue(10)：1048-1051,4.DOI:10.3969/j.issn.2095-5227.2015.10.023
哺乳动物雷帕霉素靶蛋白复合体1在心肌缺血再灌注损伤中作用的研究进展
Advances in mTORC1 in myocardium ischemia/reperfusion injury
摘要
Abstract
The mammalian target of rapamycin (mTOR) is a conservative and atypical serine/threonine kinase which exerts its main functions through 2 different multi-protein complexes, named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) respectively. Recent studies have demonstrated that mTORC1 plays a pivotal cardioprotective role in phase of myocardial ischemia as well as reperfusion through modulating autophagy, activation of mitochondrial permeability transition pore (mPTP) and upregulation of antioxidant genes. This article reviews the structure of mTOR complexes and the pivotal role of mTORC1 signaling during the injury process of myocardial ischemia and reperfusion respectively.关键词
哺乳动物雷帕霉素靶蛋白复合体 1/心肌/缺血再灌注损伤/自噬Key words
mammalian target of rapamycin complex 1/myocardium/ischemia-reperfusion injury/autophagy分类
医药卫生引用本文复制引用
范文斯,黄炜,曹丰..哺乳动物雷帕霉素靶蛋白复合体1在心肌缺血再灌注损伤中作用的研究进展[J].解放军医学院学报,2015,(10):1048-1051,4.基金项目
国家杰出青年科学基金(81325009)；国家973基础研发计划(2012CB518101)Supported by the National Science Found for Distinguished Young Scholars (81325009) （81325009）
National“973”Program for Basic Research of China(2012C B518101) （2012C B518101）
