解放军医学院学报Issue(11)：1085-1088,4.DOI:10.3969/j.issn.2095-5227.2015.11.007
卡培他滨联合吉西他滨或长春瑞滨治疗复发转移性乳腺癌的疗效观察
Capecitabin combined with gemcitabine/vinorelbine in treatment of patients with recurrent metastatic breast cancer
王英哲 1司文 2令狐锐霞 1张兴洋 1吉铁凤 1赵冬梅 1杨俊兰1
作者信息
- 1. 解放军总医院 肿瘤内科，北京 100853
- 2. 南开大学医学院，天津 300071
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of gemcitabine/vinorelbine combined with capecitabin in treatment of patients with recurrent metastatic breast cancer.Methods Seventy-five patients diagnosed with recurrent metastatic breast cancer in Chinese PLA General Hospital from January 1, 2008 to May 1, 2014 were enrolled in this study. Of the 75 cases, 42 patients were treated with gemcitabine and capecitabin (GX), 33 patients were treated with vinorelbine and capecitabin (NX).Results In GX regimen group, the objective response rate was 16.7%, the disease control rate was 85.7%, the clinical benefit rate was 45.2%, and the time-to-progression was 5.68 (95%CI: 3.679-7.689) months. In NX regimen group, the objective response rate was 29.3%, the disease control rate was 74.8%, the clinical benefit rate was 51.5%, and the time-to-progression was 8.25 (95%CI: 3.717-12.776) months. The efficacy of NX regimen infirst-line chemotherapy was superior to multi-line chemotherapy. Conclusion Both treatments are well tolerated. NX regimen may have a better efficacy infirst-line chemotherapy.关键词
转移性乳腺癌/药物疗法/卡培他滨/吉西他滨/长春瑞滨Key words
metastatic breast cancer/drug therapy/capecitabin/gemcitabine/vinorelbine分类
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王英哲,司文,令狐锐霞,张兴洋,吉铁凤,赵冬梅,杨俊兰..卡培他滨联合吉西他滨或长春瑞滨治疗复发转移性乳腺癌的疗效观察[J].解放军医学院学报,2015,(11):1085-1088,4.
