摘要
Abstract
Objective To explore application of serum homocysteine ,cystatin C and urine β2-microglobulin joint detection in diabetic nephropathy .Methods The 102 cases of diabetic nephropathy were divided into A ,B ,C three groups by urinary albumin excretion rates :normal albumin group A (42 cases)、albumin group B (35 cases) , large amounts of albumin group C (25 cases) .At the same time to 20 healthy subjects served as normal control group .Serum homocysteine ,serum cystatin C ,urine protein and urineβ2-microglobulin levels were detected .The de-tection results were used the SAS statistical software to deal with statistics for comparative analysis .Results Serum homocysteine ,systatin C and urineβ2-microglobulin were statistically different between diabetic nephropathy groups (P<0 .01) .Serum homocysteine ,serum cystatin C and urineβ2-microglobulin detection values of 102 cases with dia-betic nephropathy were analyzed by multiple linear correlation ,these were positive correlation (r= 0 .250 ,0 .410 , 0 .365 ,P<0 .01) .Conclusion Serum homcysteine ,serum cystatin C and urine β2-microglobulin joint detection can infer diabetic nephropathy damage degree ,which can evaluate renal damage in diabetes and suggest clinical interven-tion of blood homocysteine levels earlier .关键词
同型半胱氨酸/胱抑素C/β2-微球蛋白/糖尿病肾病Key words
homocysteine/cystatin C/β2-microglobulin/diabetic nepnropathy
