检验医学与临床Issue(1)：41-42,44,3.DOI:10.3969/j.issn.1672-9455.2013.01.019
N 端脑钠肽原在新生儿窒息后心肌损伤中的检测及意义
Plasma levels of N-terminal pro-brain natriuretic peptide with asphyxia complicated by myocardial in jury and the clini-cal significance
陈邹阳1
作者信息
- 1. 湖北省江陵县人民医院检验科 434100
- 折叠
摘要
Abstract
Objective To investigate the changes and the clinical significance of N-terminal pro-brain natriuret-ic peptide(NT-proBNP) levels in neonates with asphyxia complicated by myocardial injury .Methods Ninety-nine ne-onates with asphyxia(54 mild ,45 severe) were enrolled .Of the 99 neonates ,47 had myocardial injury and 52 did not develop myocardial injury .Forty-five healthy neonates served as a control group .Plasma levels of NT-proBNP were measured by using ELISA ,Myocardial enzymes and cardiac troponin I were simultaneously measured ,and electro car-diograph and chest radiographs were obtained .Results The plasma levels of NT-proBNP in neonates with myocardi-al injury were significantly higher than those in neonates without myocardial injury and in the control group ( P<0 .01) .The neonates with severe asphyxia had significantly increased plasma NT-proBNP comparing to those with mild asphyxia and the control group(P<0 .01) .Spearman rank correlation analysis showed that plasma NT-proBNP level was positively correlated in neonates with asphyxia .Plasma levels of NT-proBNP were also positively correlated with plasma levels of CK-MB ,CK and LDH (P<0 .01) .Conclusion NT-proBNP can be used as the biomarker of myocardial injury in neonates with asphyxia .The measurement of plasma NT-proBNP levels is useful in early identifi-cation of myocardial injury and severity evaluation in neonates with asphyxia .关键词
窒息/心肌损伤/N端脑钠肽原/新生儿Key words
asphyxia/myocardial injury/NT-proBNP/neonate引用本文复制引用
陈邹阳..N 端脑钠肽原在新生儿窒息后心肌损伤中的检测及意义[J].检验医学与临床,2013,(1):41-42,44,3.
