摘要
Abstract
Objective To study clinical effects of long-term and low-dose clarithromycin in treatment of chron-ic rhinosinusitis .Methods 83 patients in Affiliated Hospital of Yan′an University for treatment of chronic rhinosi-nusitis from August 2010 to October 2012 year were randomly divided into experimental group (42 cases) and control group(41 cases) .The experimental group with small dose of oral clarithromycin for 12 weeks ,control group with oral amoxicillin and clavulanate potassium for 4 weeks .Then the situation of signs and symptoms of the two groups were evaluated after treatment .Results 27 cases were cured ,10 cases were effective ,and the total effective rate was 88 .10% in experimental group .21 cases were cured ,9 casese were ffective ,and the total effective rate was 73 .17% in control group .The difference was statistically significant (P<0 .05) .The incidence of adverse reactions such as nau-sea ,abdominal pain and headache patients was 1 case respectively in experimental group ,and the incidence of adverse reaction was 7 .14% (3/42) .Nausea and vomiting were 5 cases ,diarrhea were 3 cases ,asthma was 1 cases ,and the in-cidence of adverse reaction was 21 .95% (9/41) in control group .The difference was statistically significant ( P<0 .05) .Conclusion Using small dose clarithromycin for long time in the treatment of chronic rhinosinusitis might have good curative effect ,drug safety and tolerance .关键词
克拉霉素/慢性鼻-鼻窦炎/长期小剂量治疗Key words
clarithromycin/chronic rhinosinusitis/long term low dose treatment
