摘要
Abstract
Objective Evaluate the diagnosis value of anti-cyclic citrullinated antibody (anti CCP antibody ) combined with rheumatoid factor (RF) for rheumatoid arthritis (RA) .Methods From May 2011 to September 2011 ,202 patients with rheumatic disease were selected ,including RA group ,and non-RA group .The quantitative chemiluminescence method to detect anti-CCP antibody ,immune turbidimetric assay to test RF ,and the results were analyzed statistically .Results The diagnostic test sensitivity of anti-CCP antibody ,specificity ,positive and the nega-tive predictive value were ,78% ,80 .6% ,82 .5% ,75 .8% ;RF :89 .9% ,52 .7% ,69% ,81 .7% .To analyze parallel and series test after anti-CCP antibody combined with RF detection ,The above indexes were ,parallel:93 .6% ,51 .6% , 69 .4% ,87 .3% ;series :74 .3% ,81 .7% ,82 .7% ,73 .1% ;The result of comparison in the RA group sensitivity :RF and anti-CCP antibody+RF series testing compared to individual CCP testing was significantly different (P<0 .05) , Beside ,Anti-CCP antibody+RF parallel testing and RF testing was significantly different (P<0 .05) .In the mean of anti-CCP antibody and RF positive results ,RA group and RA group was significantly difference .Conclusion Detec-tion of anti CCP antibody Combined with RF could provide clinical diagnosis for RA than individual testing .It could avoid leakage diagnosis caused by the low anti-CCP antibody sensitivity ,and misdiagnosis caused by RF low specifici-ty ,and provided the basis for clinical early diagnosis .关键词
类风湿因子/类风湿关节炎/抗环瓜氨酸肽抗体Key words
rheumatoid factor/rheumatoid arthritis/anti-cyclic citrullinated peptide antibody
