检验医学与临床Issue(20)：3019-3022,4.DOI:10.3969/j.issn.1672-9455.2015.20.019
红细胞体积分布宽度和超敏C反应蛋白与冠心病的相关性研究
Study on correlation between red blood cell distribution width and high sensitive C-reactive protein with coronary heart disease
摘要
Abstract
Objective To investigate the correlation between the red blood cell distribution width (RDW) and high sensitive C reactive protein(hs‐CRP) with coronary heart disease(CHD) .Methods 146 cases of CHD were se‐lected as the CHD group and divided into the stable angina pectoris (SAP) group(66 cases) ,unstable angina pectoris (UAP) group(53 cases) and acute myocardial infarction (AMI) group(27 cases) .Contemporaneous 70 cases of healthy physical examination were selected as the control group .RDW ,Hb ,RBC count ,WBC count ,MCV ,Hct , PLT ,MPV ,HDL ,LDL ,TC ,TG ,Cr ,BUN ,UA ,GLU ,TBIL and hs‐CRP levels were detected in each group .The ROC curve was adopted to evaluate the diagnostic value of RDW and hs‐CRP to CHD and the multivariate Logistic regression analysis was applied to predict the independent risk factors of CHD .Results Compared with the control group ,LDL ,hs‐CRP and RDW levels in the CHD group were increased significantly ,the differences were statistically significant(P<0 .05) .Serum hs‐CRP and RDW levels in the AMI group were significantly higher than those in the SAP group(P< 0 .01) ,moreover serum hs‐CRP level was significantly higher than that in the UAP group (P<0 .05) .The serum hs‐CRP and RDW levels in the multi vessels lesion group were significantly higher than those in the single vessel lesion group and double vessels lesion group (P<0 .01) ,moreover the RDW level in the double ves‐sels lesion group was significantly higher than that in the single vessel disease group (P<0 .05) .The area under curve (AUC) of ROC curves of RDW and hs‐CRP were that and 95% confidence interval of RDW and hs‐CRP were 0 .769 (95% CI:0 .683 -0 .842) ,0 .732 (95% CI:0 .656 -0 .820) .The optimal critical value of RDW and hs‐CRP were 14 .65% and 5 .92 mg/L ,the sensitivity and the the specificity were0 .769(95% CI:0 .683 -0 .842) and 0 .732(95%CI:0 .656-0 .820) respectively .The optimal critical values of RDW and hs‐CRP were hs‐CRP ,their sensitivity and specificity were 75 .8% ,61 .7% and 74 .5% ,62 .1% respectively .The multivariate Logistic regression analysis showed that RDW ,HDL ,smoking history and gender entered to the regression model ,the regression coefficients were 0 .624 ,7 .254 ,0 .630 and 0 .947 respectively .Conclusion RDW and hs‐CRP are associated with the severity of coronary artery lesions and CHD ,high level of RDW may be an independent risk factor of CHD .关键词
红细胞体积分布宽度/超敏C反应蛋白/冠心病/冠状动脉造影Key words
red blood cell distribution width/high sensitivity C-reactive protein/coronary heart disease/coronary angiography引用本文复制引用
孙京花,李健,王成彬..红细胞体积分布宽度和超敏C反应蛋白与冠心病的相关性研究[J].检验医学与临床,2015,(20):3019-3022,4.基金项目
国家科技支撑计划课题（2012BAK25B0101）。 （）
