摘要
Abstract
Objective To explore the correlations between serum vascular endothelial growth factor (VEGF) level with clinicopathological parameters in the patients with lung cancer and breast cancer ,and the significance of the combined diagnosis of CEA ,NSE ,CYFRA21‐1 ,SCC and CA15‐3 .Methods Serum VEGF level was detected by ELISA in 77 patients with lung cancer ,41 patients with breast cancer and 164 healthy controls .Serum CEA ,NSE , CYFRA21‐1 and SCC levels in lung cancer patients and serum CEA ,CA15‐3 levels in breast cancer patients were de‐tected by electrochemiluminescence immunoassay (ECLIA) .The detection results were performed the statistical anal‐ysisResults The serum VEGF levels in the lung cancer group and the breast cancer group were (234 .08 ± 187 .33) pg/mL and(229 .20 ± 187 .33) pg/mL respectively ,which were significantly higher than those in the healthy control group of lung cancer and the control group of breast cancer (Z= -4 .196 ,t= -3 .810 ,P<0 .05) .Serum VEGF level and tumor size had the statistical significance(t= -2 .520 ,P<0 .05) .The sensitivities of VEGF for the diagnosis of lung cancer and breast cancer were 62 .3% and 61 .0% respectively ,which were significantly higher than those in the other common clinical tumor markers and their specificities were 82 .0% and 70 .7% respectively .The sensitivities of the combined detection of VEGF ,CEA ,NSE ,CYFRA21‐1 ,SCC and CA15‐3 for diagnosing lung cancer and breast cancer were 80 .5% and 70 .4% respectively .Conclusion The combined detection of VEGF with CEA ,NSE ,CY‐FRA21‐1 ,SCC and CA15‐3 can significantly improve the diagnostic sensitivities to lung cancer and breast cancer , which may have an important clinical significance for the screening and clinical diagnosis of lung cancer and breast cancer .关键词
血管内皮生长因子/肿瘤标志物/肺癌/乳腺癌Key words
vascular endothelial growth factor/tumor markers/lung cancer/breast cancer
