检验医学与临床Issue(20)：3052-3054,3.DOI:10.3969/j.issn.1672-9455.2015.20.032
皮肌炎患者抗核抗体和抗 Jo-1抗体检测的临床意义
Clinical significance of antinuclear antibody and anti-Jo-1 antibody detection in patients with dermatomyositis
叶杨 1高晓梅 1杨南萍1
作者信息
- 1. 泸州医学院附属医院风湿免疫科，四川泸州 646000
- 折叠
摘要
Abstract
Objective To investigate the clinical significance of common autoantibodies including antinuclear antibody(ANA) and anti‐synthetase antibody(Jo‐1)in dermatomyositis .Methods 280 hospitalized patients with der‐matomyositis in our hospital were selected and divided into the ANA positive and Jo‐1 positive group(group A ,70 ca‐ses) ,ANA positive and Jo‐1 negative group(group B ,80 cases) ,ANA negative and Jo‐1 positive group(group C ,70 cases) and ANA negative and Jo‐1 negative group(group D ,60 cases) .The changes of muscle enzymes ,visceral organ damages and features of laboratory related indexes were analyzed in the four groups .Meanwhile ,the correlation be‐tween the ANA level and muscle enzymes was analyzed .Results Compared with the group D ,the muscle enzymes in the group A and C were significantly increased(P<0 .05) ,moreover the incidence of lung and heart damages also was significantly increased ,(P<0 .05) ,while the increase of muscle enzymes in the group B was unapparent (P>0 .05) , moreover the muscle enzymes had no correlation with the ANA titer level (P> 0 .05) .Conclusion Jo‐1 antibody could correctly reflect the illness severity of dermatomyositis .关键词
皮肌炎/抗核抗体/抗Jo-1抗体Key words
dermatomyositis/antinuclear antibody/anti-Jo-1 antibody引用本文复制引用
叶杨,高晓梅,杨南萍..皮肌炎患者抗核抗体和抗 Jo-1抗体检测的临床意义[J].检验医学与临床,2015,(20):3052-3054,3.
