检验医学与临床Issue(20)：3055-3057,3.DOI:10.3969/j.issn.1672-9455.2015.20.033
拉米夫定和阿德福韦酯抗病毒疗效与 HBV 基因型的关系
Correlation between HBV genotype and the antiviral efficacy of lamifuding and adefovir dipivoxil
摘要
Abstract
Objective To explore the relationship between the antiviral therapy efficacy of lamifuding and ade‐fovir dipivoxil with HBV genotypes in chronic hepatitis B (CHB) .Methods 125 cases of CHB patients were selected and treated lamivudine (lamivudine group ,n=60) and adefovir dipivoxil (adefovir dipivoxil group ,n=65) .The virus response rates ,serological response rates and biochemical response rates of two groups were observed respectively af‐ter 3 ,6 ,12 months treatment .The drug resistance rates and mutation sites of drug resistance gene were detected after 12 months treatment .Results In lamivudine group ,patients infected genotype B HBV had higher virus response rate and serological response rate than patients infected genotype C HBV after 6 and 12 months treatment (P<0 .05) , while the biochemical response rates had no significant difference between two genotypes (P>0 .05) .In adefovir dip‐ivoxil group ,there were no significant difference of virus response rates ,serological response rates and biochemical re‐sponse rates between patients infected genotype B and genotype C HBV (P> 0 .05) during treatment .After 12 months treatment ,the drug resistance rate of lamivudine group was higher than adefovir dipivoxil group (P<0 .05) . The main mutation sites of drug resistance gene of lamivudine group and adefovir dipivoxil group were rt 108M and rt236T respectively .Conclusion Lamivudine has better antiviral efficacy for genotype B HBV than genotype C HBV ,while the antiviral efficacy of adefovir dipivoxil is independent with HBV genotypes .The drug resistance of HBV should be paid attention to during treatment ,and the assessment of efficacy should also be strengthened .关键词
乙型肝炎病毒/基因型/拉米夫定/阿德福韦酯Key words
hepatitis B virus/genotype/lamivudine/adefovir dipivoxil引用本文复制引用
刘键,陆学东,黄烈,庄鹏,王琼,吴润香,杨来智..拉米夫定和阿德福韦酯抗病毒疗效与 HBV 基因型的关系[J].检验医学与临床,2015,(20):3055-3057,3.基金项目
广东省深圳市福田区公益性科研项目（FTWS081）。 （）
