检验医学与临床Issue(20)：3073-3074,3077,3.DOI:10.3969/j.issn.1672-9455.2015.20.040
2型糖尿病患者高血清游离脂肪酸水平与胰岛素抵抗的相关性研究
The relationship of insulin resistance and serum high free fatty acid level in patients with type 2 diabetes mellitus
郝建军 1冯晓鸿 2吴孝田1
作者信息
- 1. 江苏省高邮市中医医院检验科 225600
- 2. 江苏省高邮市人民医院检验科 225600
- 折叠
摘要
Abstract
Objective To investigate the relationship of serum free fatty acid (FFA ) level and insulin resist‐ance in patients with type 2 diabetes mellitus (T2DM ) .Methods A total of 102 T2DM patients were enrolled (T2DM group) ,and divided into well‐control group and poor‐control group according to their glycosylated hemoglo‐bin (HbA1c) levels .Moreover ,62 healthy people were recruited as normal control group .All of the subjects were un‐derwent measurement of triglyceride (TG ) ,HbA1c ,fast blood glucose (FBS ) ,2 h postprandial blood glucose (PPBS) ,fast insulin (FINS) ,fast FFA and 2 h postprandial FFA (2hFFA) .And the insulin resistance index (HO‐MA‐IR) was evaluated by homeostasis model .Results The levels of HbA1c ,TG ,FBS ,PPBS ,FFA ,2hFFA and HO‐MA‐IR in T2DM group were significantly higher than those in normal control group (P<0 .05) .And these parame‐ters in poor‐control group were higher than those in well‐control group(P<0 .05) .FFA and 2hFFA were positively correlated with other parameters (r>0 .5 ,P<0 .01) .Conclusion The serum level of FFA increased in T 2DM pa‐tients ,which related with insulin resistance .关键词
2型糖尿病/游离脂肪酸/胰岛素抵抗Key words
type 2 diabetes mellitus/free fatty acid/insulin resistance引用本文复制引用
郝建军,冯晓鸿,吴孝田..2型糖尿病患者高血清游离脂肪酸水平与胰岛素抵抗的相关性研究[J].检验医学与临床,2015,(20):3073-3074,3077,3.
