检验医学与临床Issue(21)：3144-3146,3149,4.DOI:10.3969/j.issn.1672-9455.2015.21.005
类风湿关节炎患者外周血T淋巴细胞亚群 CD4＋／CD8＋表达的意义
Expression and significance of peripheral blood T-lymphocytes subsets CD4/CD8 in patients with rheumatoid arthritis
摘要
Abstract
Objective To investigate the correlation between the change of peripheral blood T‐lymphocyte subsets CD4/CD8 with the disease progress in the patients with rheumatoid arthritis (RA) .Methods The peripheral blood T‐lymphocytes subsets CD4/CD8 in 94 patients with RA and 22 healthy controls were examined by flow cy‐tometry .94 cases of RA were divided into low value ,median value and high value groups by RA disease activity index (DAS28) scores .Results Compared with the healthy controls ,the expression rate of peripheral blood CD3+CD4+ T cells in the RA group was increased significantly (P<0 .05) ,in which CD3+CD4+ T cells were (41 .03 ± 9 .53)% in DAS28 low value group ,(42 .16 ± 7 .08)% in DAS28 median value group and (43 .72 ± 9 .63)% in DAS28 high value group .The expression rate of CD3+CD8+ T was significantly decreased (P<0 .05) ,in which CD3+CD8+ T cells were (21 .33 ± 6 .67)% in DAS28 low value group ,(21 .39 ± 7 .36)% in DAS28 median value group and (21 .28 ± 6 .60)%in DAS28 high value group .Conclusion CD4+ /CD8+ ratio is associated with RA progression ,indicating that the CD4+ /CD8+ imbalances plays an important role in the pathogenesis of RA .关键词
类风湿关节炎/流式细胞/T淋巴细胞亚群Key words
rheumatoid arthritis/flow cytometry/T-lymphocytes subsets引用本文复制引用
梅序桥,吴阿阳,郑燕苹,陈宏浦,郑源海,杨惠聪,张佳林..类风湿关节炎患者外周血T淋巴细胞亚群 CD4＋／CD8＋表达的意义[J].检验医学与临床,2015,(21):3144-3146,3149,4.基金项目
福建省卫生厅青年科研课题立项（2011-2-51）。 （）
