检验医学与临床Issue(21)：3186-3188,3191,4.DOI:10.3969/j.issn.1672-9455.2015.21.021
ROC曲线及 Logistic 回归评价肿瘤标志物在结直肠癌的诊断价值
Evaluation of ROC curve and Logistic regression on diagnostic value of various tumor markers for colorectal cancer
耿有全 1张诗颜 1林必定1
作者信息
- 1. 福建中医药大学附属福鼎医院，福建福鼎 355200
- 折叠
摘要
Abstract
Objective To evaluate the diagnostic capacity of the combined detection of carcino‐embryonic anti‐gen(CEA) ,carbohydrate antigen 199(CA199) ,carbohydrate antigen 125(CA125) and thymidine kinase 1 (TK1) for colorectal cancer (CRC) .Methods Serum levels of CEA ,CA199 ,CA125 and TK1 were measured in 135 patients with CRC and 105 patients with benign colorectal diseases .The Logistic regression model was used to draw the re‐ceiver operating characteristic (ROC) curves and the area under curve(AUC) was calculated for evaluating the diag‐nostic value of various tumor markers .Results In the evaluation of diagnostic capacity in the CRC group and the be‐nign colorectal diseases group ,the serum levels of CEA ,CA199 ,CA125 and TK1 in the CRC group were significantly higher than those in the benign colorectal diseases group ,the differences were statistically significant (P<0 .01) .The optimal cut‐off values of various ROC curves were 3 .36 μg/L for CEA ,8 .15 kU/L for CA199 ,10 .95 kU/L for CA125 and 1 .62 pmol/L for TK1 .The AUC of ROC curves were 0 .694 for CEA ,0 .688 for CA199 ,0 .717 for CA125 ,0 .660 for TK1 and 0 .793 for the combination detection .The combination detection had a higher Youden in‐dex and its sensitivity reached 71 .9% .Conclusion The combined detection of serum CEA ,CA199 ,CA125 and TK1 could play complementary role in the diagnosis of CRC and could significantly improve the sensitivity for the diagno‐sis of CRC .关键词
结直肠癌/癌胚抗原/糖类抗原199/糖类抗原125/胸苷激酶1Key words
colorectal cancer/carcino-embryonic antigen/carbohydrate antigen 199/carbohydrate anti-gen 125/thymidine kinase 1引用本文复制引用
耿有全,张诗颜,林必定..ROC曲线及 Logistic 回归评价肿瘤标志物在结直肠癌的诊断价值[J].检验医学与临床,2015,(21):3186-3188,3191,4.
